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  • 產(chǎn)品名稱：C9orf116 抗原（重組蛋白）

  • 產(chǎn)品型號(hào)：100ug
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價(jià)格：800
  • 產(chǎn)品庫存：35
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詳情介紹：

中文名稱： C9orf116 抗原（重組蛋白）

英文名稱： C9orf116 Antigen (Recombinant Protein)

別     名： chromosome 9 open reading frame 116; PIERCE1; RbEST47

儲(chǔ)     存： 冷凍（-20℃）

相關(guān)類別：抗原

概     述

Fusion protein corresponding to a region derived from 1-92 amino acids of human C9orf116


技術(shù)規(guī)格

Full name:

chromosome 9 open reading frame 116

Synonyms:

PIERCE1; RbEST47

Swissprot:

Q5BN46

Gene Accession:

BC021261

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

C9orf116, also known as PIERCE1. PIERCE1 is an important p53 target gene contributing to normal DNA damage response and may play crucial roles in maintaining genomic integrity against genotoxic stresses, including UVC irradiation. PIERCE1 exists as two alternatively spliced isoforms and is predominantly expressed in human small cell lung cancer. PIERCE1 knockdown induces down-regulation of proapoptotic genes including Ei24, Apaf1 and PTEN, suggesting that PIERCE1 is a proapoptotic gene. It is helpful for in-depth understanding of p53 pathways and the design of new cancer therapies.





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